Researching the mental effects of chemicals on humans is notoriously difficult and complicated, not least because of the immense amount of ways that a certain person may react to any given substance, the huge number of external factors that may be involved in a psychological outcome, and the difficulty in quantifiably measuring many mental effects. Add to this the sometimes extreme politicisation and bias of results that comes when researching controversial topics like the use of illegal drugs and one can see that researching the mental effects of banned-but-fun substances is especially troublesome.
This trouble is often seen in mass-media reports of such experiments. Often, presumably in order to make the "news" exciting and dramatic for their readers the "shock horror - you will die if you even look at illegal drugs" conclusions are heightened to the max, and any opposing conclusions, grey areas and other interpretations of the same data are ignored. Not only does this undermine any sensible attempt at presenting results with potentially important public health conclusions to the public at large, but research suggests that it could be this very style of reporting that causes some of the mental problems it shouts about so loudly.
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